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Be especially cautious when pregnant. According to Dr. Cameron Wolfe, an infectious disease specialist at Duke University Medical Center, women who are pregnant are at a higher risk of complications and even death from influenza. Doctors don't fully understand why, but many feel that because the flu can compromise a woman's ability to breathe well, this makes it difficult for oxygen to be passed on to the fetus. Pregnant women should speak with their obstetricians about the safety of the flu shot.